Pope Leo XIV

The event ends the pontiff’s first international trip that took him to Muslim-majority countries with different Christian denominations.

The pontiff sought to lift the country's long-suffering people and bolster a crucial Christian community in the Middle East.

Leo undertook the tour "in a spirit of reflection and listening, with deep respect for the place and for the faith of those who gather there in prayer," the Vatican said.

Leo paid tribute to the country's tiny Catholic community and also visited a group of nuns, the Little Sisters of the Poor, who run a nursing home in Istanbul.

Ahead of his visit, Leo shared a Thanksgiving message with NBC News encouraging all people "to recognize that we have all received so many gifts."

NBC's Molly Hunter spoke with Pope Leo XIV outside his lakeside residence, Castel Gandolfo.

The pope praised cinema's power to elevate stories often left out of the mainstream.

The Vatican insists the items were "gifts" to Pope Pius XI, but Indigenous groups and experts have long called for their return.

The event marked the first time since the Reformation that the heads of the two Christian churches, divided for centuries, have prayed together.

The pope, who didn't single out any country for its treatment of migrants, called on Catholics to “open our arms and hearts to them, welcoming them as brothers and sisters.”

Leo made clear he is not a Trump supporter, adding that he and his brother, a self-described "MAGA-type," are in "different places" politically.